A-162 Neuropsychiatric Elevations in Epilepsy Patients with and without Severe Memory Impairment

Abstract Objective Severe memory impairment in epilepsy is associated with increased difficulties daily living that extend beyond the limitations of having seizure disorder and create greater emotional burden. Accordingly, current study explored psychopathological differences between patients without severe impairment. Method This retrospective chart review included 78 adults who underwentneuropsychological testing a hospital setting. Most participants (78%) had temporallobe epilepsy. Study measures Word Memory Test (WMT), cognitive measures, self-report Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF). Genuine Impairment Profile (GMIP) on WMT was used as an indicator memorydeficit. Results GMIP group 30 significantly higher number males (Χ 2 (1) = 4.929, p 0.03). Significantly lower performances overall functioning were seenin group. As expected, mean scores across all MMPI-2-RF order scales majority Specific Problem Scales, however only Substance Abuse Scale showed statistically significant difference (t(76) −1.96, 0.05). Conclusions Those non-significant tendency to obtain scoreson most indices psychopathology elevation concerning substance abuseproblems. decline may have risk for abuse problemsthat can be reduced treatment effectiveness provoke seizures due either acuteneurotoxicity or withdrawal. Additional studies larger samples are needed characterizesubstance problems decline.